The Sevilleta Long-Term Ecological Research (LTER) program, based in New Mexico, aims to expand our understanding of the biological processes in drylands. We are addressing big questions in ecology, centered on temporal environmental variability, or the unpredictability of the abiotic environment over time. The fluctuating nature of drylands makes them excellent study systems to improve general understanding of the biological consequences of environmental variability. Building on this focus, our research is structured around five main questions that guide our investigation into how organisms and ecosystems respond to changing environmental conditions.